Tutorial

Translation between single-cell transcriptomes and DNA methylomes

scBOND could make translation between single-cell transcriptomes and DNA methylomes paired data using scBOND model in scBond.bond.

• scBOND usage

Extension usages of scBOND framework

scBOND provide a series of extension usage with preprocessing in scBond.data_processing and model in scBond.train_model (scRNA-seq ~ scDNAm data)

Translation based on data augmentation

Based on cell-type labels, scBOND could make translation after data augmentation strategy scBond.bond.Bond.augmentation.

• scBOND_Aug using augmentation with cell-type labels

Translation from single-modal data to another modality

After training, scBOND could use single scRNA-seq to predict single scDNAm in scBond.train_model.Model.predict_single_methylation and use single scDNAm to predict single scRNA-seq in scBond.train_model.Model.predict_single_rna.

• scBOND for single modality prediction